Research suggests that phenylephrine that’s taken by mouth is not safe for pregnant women. This is because of the way phenylephrine works. The drug relieves nasal congestion by narrowing the blood vessels in your nasal passages. This reduces the secretions in the nasal passages and opens up the airways.
Is phenylephrine safe during pregnancy?
Pseudoephedrine and phenylephrine are pregnancy category C in all three trimesters of pregnancy. The American College of Obstetricians and Gynecologists (ACOG) and the American College of Allergy, Asthma and Immunology (ACAAI) recommend using pseudoephedrine during pregnancy.
What birth defects are caused by phenylephrine?
First-trimester use of phenylephrine, which is found in Sudafed among other products, was tied to an eight-fold higher risk of a heart defect called endocardial cushion defect. And phenylpropanolamine (Acutrim) was also linked to an eight-fold risk of defects of the ear and a three-fold increase in stomach defects.
Why are decongestants bad during pregnancy?
Some decongestants, especially ones that contain pseudoephedrine, can cause elevations in blood pressure, so patients with chronic or pregnancy-induced high blood pressure should stay away from those medications.
What decongestants are safe to take while pregnant?
Decongestant medications reduce stuffiness and sinus pressure by constricting the blood vessels in your nose, which reduces swelling. Pseudoephedrine and phenylephrine are available over the counter as Sudafed and are safe for many women to use during pregnancy.
How long does phenylephrine stay in system?
The elimination half life of phenylephrine is about 2.5 to 3.0 hours. The clinical effects of a single intravenous bolus dose of phenylephrine are short lived and needs to be repeated every 10–15 minutes.
What is Pregnancy Category C mean?
Category C. “Either studies in animals have revealed adverse effects on the fetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the fetus.”
Can nasal spray cause birth defects?
“Pregnant women who use nasal sprays for colds and hayfever increase the risk of rare birth defects,” reports the Mail Online. “Pregnant women who use nasal sprays for colds and hayfever increase the risk of rare birth defects,” reports the Mail Online.
Is it OK to take pseudoephedrine while pregnant?
Sudafed (Pseudoephedrine) 30-60 mg every 4-6 hours can be used in the second and third trimesters in women without gestational hypertension. Avoid use in the first trimester and with breastfeeding. Sudafed PE (Phenylephidrine) should be avoided because of its uncertain efficacy and safety in pregnancy.
What is better pseudoephedrine or phenylephrine?
Studies have shown that pseudoephedrine is a much more effective decongestant than phenylephrine. Phenylephrine’s decongestant effects may not be significantly different from that of a placebo. The effects of both drugs may be augmented with concurrent use of other products that affect rhinitis, such as antihistamines.
What is the safest decongestant?
In the drug realm, antihistamines such as diphenhydramine (Benadryl), chlorpheniramine (Chlor-Trimeton), cetirizine (Zyrtec), and loratadine (Claritin) can help with a stuffy nose are safe for the heart.
Is nasal decongestant spray safe during pregnancy?
Corticosteroid nasal sprays containing beclomethasone and budesonide are considered safe to use during pregnancy. Decongestant nasal sprays may be used if corticosteroid and antihistamine nasal sprays have not relieved the symptoms.