All formulations of acyclovir are assigned FDA pregnancy category C status ****, which indicates that safety in human pregnancies has not been determined; therefore, the drug should not be used during pregnancy unless the potential benefit justifies the potential risk to the fetus.
Can acyclovir be used in pregnancy?
Conclusion: Use of acyclovir in the first trimester does not increase birth defects, and it should be the antiviral drug of choice in early pregnancy.
What category/class is acyclovir?
Acyclovir is in a class of antiviral medications called synthetic nucleoside analogues.
What pregnancy category is valacyclovir?
The US Food and Drug Administration has classified acyclovir, valacyclovir, and famciclovir as category B drugs in pregnancy. Information on the safety of acyclovir, with regard to teratogenicity in humans, is mainly based on data from a pregnancy registry managed by the drug manufacturer.
What is pregnancy Category B?
Category B drugs include prenatal vitamins, acetaminophen and several other medications used routinely and safely during pregnancy. If there is a clinical need for a Category B drug, it is considered safe to use it.
Does acyclovir cross the placenta?
Acyclovir is known to cross the placenta to the fetus. Frenkel et al4 reported the specific pharmacokinetics of acyclovir in pregnant patients with recurrent HSV receiv ing either 200 or 400 mg of acyclovir orally every 8 hours from 38 weeks’ gestation until delivery.
Does acyclovir cause miscarriage?
Does taking acyclovir/valacyclovir increase the chance for miscarriage? Miscarriage can occur in any pregnancy. Studies have not found an increased chance for miscarriage following acyclovir use.
Does acyclovir weaken immune system?
We studied the immune response to CMV in patients who were taking acyclovir to assess if therapy could be used to suppress the CMV-specific immune response. The T cell reactivity against the immunodominant late viral protein pp65 was reduced by 53% in people who were taking acyclovir.
Can you take acyclovir everyday?
Typical dosage for prevention of recurrent herpes: 400 mg twice per day, every day for up to 12 months. Other dosing plans may include doses ranging from 200 mg three times daily to 200 mg five times daily. Your doctor will decide how long you should take this drug to avoid a flare-up of the infection.
Can acyclovir harm my baby?
No evidence links acyclovir or valacyclovir to serious side effects in infants born to mothers who took these drugs during pregnancy. Treatment with these drugs usually starts around the 36th week of pregnancy.
Taking antiviral medications can prevent serious flu complications, such as pneumonia. Although it’s important to be cautious with any medication during pregnancy, research suggests that the benefits outweigh the potential risks of antiviral medications to treat flu during pregnancy.
Why do I keep getting cold sores while pregnant?
Cold sores are a strain of herpes, meaning they are extremely contagious and can recur, says Susan Grant, M.D., an OB-GYN in New York City. They can appear at any time, especially when your body is under stress or going through hormone fluctuations, making pregnancy a prime time for outbreaks.